| Identification | Back Directory | [Name]
3-Pyridinecarboxylic acid, 2-[[(2R)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-[(1H-indol-2-ylcarbonyl)amino]-3-oxopropyl]thio]- (9CI) | [CAS]
176915-07-4 | [Synonyms]
3-Pyridinecarboxylic acid, 2-[[(2R)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-[(1H-indol-2-ylcarbonyl)amino]-3-oxopropyl]thio]- (9CI) | [Molecular Formula]
C35H33N5O4S | [MOL File]
176915-07-4.mol | [Molecular Weight]
619.73 |
| Hazard Information | Back Directory | [Description]
TP-680 is a new cholecystokininA receptor antagonist. | [Uses]
TP-680 is a cholecystokinin receptor antagonist. TP-680 binds 1510 times more strongly to rat pancreatic CCKA receptors (IC50=1.2 nM) than to rat brain CCKB receptors (IC50=1812.5 nM). TP-680 can be used in the study of gastrointestinal diseases[1]. | [IC 50]
CCKAR: 1.2 nM (IC50); CCKBR: 1812.5 nM (IC50) | [References]
[1] Akiyama T, et al. Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist[J]. British journal of pharmacology, 1996, 117(7): 1558. DOI:10.1111/j.1476-5381.1996.tb15321.x |
|
|