| Identification | Back Directory | [Name]
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- | [CAS]
176957-55-4 | [Synonyms]
CS-1839
CCT007093
CCTOO7093
CCT-007093; CCT 007093; CCT007093
2,5-Bis(2-thienylmethylene)-cyclopentanone
(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone
2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
(2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone
Cyclopentanone, 2,5-bis(2-thienylmethylene)-, (2E,5E)-
(2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone CCT007093 | [Molecular Formula]
C15H12OS2 | [MDL Number]
MFCD00121546 | [MOL File]
176957-55-4.mol | [Molecular Weight]
272.39 |
| Chemical Properties | Back Directory | [Melting point ]
222-223℃ | [storage temp. ]
2-8°C | [solubility ]
DMSO: >3mg/mL | [form ]
powder, yellow | [color ]
Light yellow to green yellow | [Sensitive ]
Light Sensitive | [InChI]
1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+ | [InChIKey]
KPFZCKDPBMGECB-WGDLNXRISA-N | [SMILES]
O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
Acts as a PPM1D inhibitor | [Biological Activity]
cct007093 is a small-molecule chemical inhibitor of ppm1d with ic50 value of 8.4μm [1].cct007093 is a thienylidene cyclopentanone and shows a potent inhibition of ppm1d in the in vitro assay when using the recombinant phospho-p38 as a substrate. in cellular assay, cct007093 shows specificity for mcf-7 cells over hela cells. it reduces 40% viability of the cells after 2 days. it is found that the cell death induced by cct007093 is dependent on p38 kinase activity. cct007093 mimics the effect of ppm1d rnai in activating p38 kinase. it induces p38 phosphorylation at 4 h post-exposure in mcf-7 cells and the loss of viability can be rescued by sb203580, the specific p38 inhibitor [1]. | [in vivo]
CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy[1].
| Animal Model: | Wild-type mice[1]. | | Dosage: | 3.2 and 6.4 mg/kg. | | Administration: | Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH). | | Result: | Significantly improved survival in mice following major hepatectomy (80% hepatectomy).
The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.
|
| [target]
WIP1 | [References]
[1] rayter s, elliott r, travers j, rowlands mg, richardson tb, boxall k, jones k, linardopoulos s, workman p, aherne w, lord cj, ashworth a. a chemical inhibitor of ppm1d that selectively kills cells overexpressing ppm1d. oncogene. 2008 feb 14;27(8):1036-44. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|