| Identification | Back Directory | [Name]
HEMATOPORPHYRIN DIHYDROCHLORIDE | [CAS]
17696-69-4 | [Synonyms]
ematoporfirina
Hemaloporphyrin
HematoporphyrineDihcl
HAEMATOPORPHYRINDICHLORIDE
HEMATOPORPHYRIN DIHYDROCHLORIDE
Haematopophyrin dihydrochloride
HAEMATOPORPHYRIN DIHYDROCHLORIDE
HEMATOPORPHYRIN IX DIHYDROCHLORIDE
HAEMATOPORPHYRIN Dihydrochloride(RG)
HEMATOPORPHYRIN DIHYDROCHLORIDE USP/EP/BP
21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr
7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid
acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor
21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr
7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid hydrochloride
8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID DIHYDROCHLORIDE
8,13-Bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid dihydrochloride
3,3'-(7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl)dipropionic acid dihydrochloride
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, hydrochloride (1:2)
HematoporphyrinIXdihydrochloride,8,13-Bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionicaciddihydrochloride | [EINECS(EC#)]
241-699-4 | [Molecular Formula]
C34H40Cl2N4O6 | [MDL Number]
MFCD00013470 | [MOL File]
17696-69-4.mol | [Molecular Weight]
671.61 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Very Dark Red | [Water Solubility ]
Insoluble in water. Soluble in pyridine (5%). | [Merck ]
14,4636 | [BRN ]
78957 | [Stability:]
Hygroscopic | [EPA Substance Registry System]
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Risk Statements ]
33 | [RTECS ]
TS5505000 | [TSCA ]
Yes | [Toxicity]
mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
| Hazard Information | Back Directory | [Description]
Hematoporphyrin is a photosensitizer.1 Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria.2 It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM.3 Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.4 | [Uses]
Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate. | [References]
[1] KESSEL D. Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy.[J]. Photochemistry and Photobiology, 1984, 39 6: 851-859. DOI: 10.1111/j.1751-1097.1984.tb08871.x
[2] C SALET G M. Photodynamic effects of haematoporphyrin on respiration and calcium uptake in isolated mitochondria.[J]. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1981, 39 2: 227-230. DOI: 10.1080/09553008114550261
[3] M. EGYEKI . DNA damaging capability of hematoporphyrin towards DNAs of various accessibilities[J]. Journal of photochemistry and photobiology. B, Biology, 2006, 84 2: Pages 119-127. DOI: 10.1016/j.jphotobiol.2006.02.005
[4] L TOMIO. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats.[J]. Acta radiologica. Oncology, 1983, 22 1: 49-53. DOI: 10.3109/02841868309134338 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|