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ISIS 5132 is a 20-base phosphorothioate oligonucleotide that specifically down-regulates c-raf expression. | [References]
[1] Rudin CM, Holmlund J, Fleming GF, et al. Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.?Clin Cancer Res. 2001;7(5):1214-1220. PMID:11350886
[2] Tolcher AW, Reyno L, Venner PM, et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.?Clin Cancer Res. 2002;8(8):2530-2535. PMID:12171880 |
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