| Identification | Back Directory | [Name]
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole | [CAS]
1772-39-0 | [Synonyms]
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole
5-Nitro-2-(4-nitrophenyl)benziMidazole, 95%
5-Nitro-2-(4-nitrophenyl)-1H-benzoimidazole | [EINECS(EC#)]
217-200-0 | [Molecular Formula]
C13H8N4O4 | [MDL Number]
MFCD00406189 | [MOL File]
1772-39-0.mol | [Molecular Weight]
284.23 |
| Chemical Properties | Back Directory | [Melting point ]
300 °C | [Boiling point ]
565.2±56.0 °C(Predicted) | [density ]
1.544±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.07±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
NSC-657186 is a novel selective non-zinc-binding MMP-2 inhibitor. | [Uses]
MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1]. | [IC 50]
MMP-2: 4.2 ± 0.2 μM (IC50); MMP13: 12 ± 7 μM (IC50); MMP-9: 23.3 ± 10. μM (IC50); MMP-8: 25 ± 10 μM (IC50) | [References]
[1] Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257. DOI:10.1016/j.bmc.2019.115257 |
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