| Identification | Back Directory | [Name]
2-(2-BROMOETHOXY)TETRAHYDRO-2H-PYRAN | [CAS]
17739-45-6 | [Synonyms]
2-(2-Bromoethoxy)oxane
2-(2-BROMO-ETHOXY)-TETRAHYDRO-PYRAN
2-BROMO-O-TETRAHYDROPYRANYL-ETHANOL
2H-Pyran,2-(2-broMoethoxy)tetrahydro-
2-(2-BroMoethoxy)tetrahydro-2H-pyran 96%
2-[(2-Bromoethyl)oxy]tetrahaydro-2H-pyran
2-(2-Bromoethoxy)tetrahydro-2H-pyran (stabilized with K2CO3) | [EINECS(EC#)]
145-859-6 | [Molecular Formula]
C7H13BrO2 | [MDL Number]
MFCD01321310 | [MOL File]
17739-45-6.mol | [Molecular Weight]
209.08 |
| Chemical Properties | Back Directory | [Appearance]
Clear pale yellow liquid | [Boiling point ]
62-64 °C0.4 mm Hg(lit.)
| [density ]
1.384 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.482(lit.)
| [Fp ]
190 °F
| [storage temp. ]
0-10°C | [form ]
clear liquid | [color ]
Colorless to Almost colorless | [Specific Gravity]
1.384 | [InChI]
InChI=1S/C7H13BrO2/c8-4-6-10-7-3-1-2-5-9-7/h7H,1-6H2 | [InChIKey]
GCUOLJOTJRUDIZ-UHFFFAOYSA-N | [SMILES]
C1(OCCBr)OCCCC1 | [EPA Substance Registry System]
2H-Pyran, 2-(2-bromoethoxy)tetrahydro- (17739-45-6) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear pale yellow liquid | [Uses]
2-(2-Bromoethoxy)tetrahydro-2H-pyran may be used in the synthesis of:
- 4-(2-chloroethoxy)benzenesulfonyl chloride
- estrogen ligands bearing carborane
- 2-(2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethoxy)-tetrahydro-2H-pyran
| [General Description]
2-(2-Bromoethoxy)tetrahydro-2H-pyran is an organic building block. It has been synthesized by employing 2-bromoethanol as a starting reagent. | [Synthesis]
To a mixed solution of 2-bromoethanol (3.8 g, 30.0 mmol) and 3,4-dihydro-2H-pyran (2.5 g, 30.0 mmol) dissolved in dichloromethane (50 mL), p-toluenesulfonic acid (380.0 mg, 2.2 mmol) was added in portions. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated and purified by silica gel column chromatography (petroleum ether/ethyl acetate, 50:1) to afford 2-(2-bromoethoxy)tetrahydro-2H-pyran (5.6 g, yield: 89%) as a colorless oil. | [References]
[1] Collection of Czechoslovak Chemical Communications, 2004, vol. 69, # 10, p. 1843 - 1876
[2] Chinese Chemical Letters, 2010, vol. 21, # 10, p. 1165 - 1166
[3] Phosphorus, Sulfur and Silicon and Related Elements, 1998, vol. 132, p. 219 - 229
[4] Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 2000, vol. 350, p. 51 - 65
[5] Patent: WO2008/76949, 2008, A2. Location in patent: Page/Page column 28 |
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