| Identification | Back Directory | [Name]
1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID METHYL ESTER | [CAS]
177478-49-8 | [Synonyms]
Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate
Methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate 97%
1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID METHYL ESTER
6-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester | [Molecular Formula]
C11H13NO2 | [MDL Number]
MFCD08692534 | [MOL File]
177478-49-8.mol | [Molecular Weight]
191.23 |
| Chemical Properties | Back Directory | [Melting point ]
73-76 °C | [Boiling point ]
349.4±31.0 °C(Predicted) | [density ]
1.123±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
powder | [pka]
2.60±0.20(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate from methyl 6-quinolinecarboxylate was as follows: carbon-loaded palladium (1.50 g, 10% mass fraction) and ammonium formate (10.5 g, 165 mmol) were added in methanol (20 mL), followed by methyl 6-quinolinecarboxylate (1.20 g, 6.41 mmol). The reaction mixture was stirred at 70°C for 2 hours. Upon completion of the reaction, the synthesis was processed according to the synthesis method of Step 1 of Example 2 to afford the white solid product methyl 1,2,3,4-tetrahydroquinoline-6-carboxylate (1.20 g) in 97.9% yield. | [References]
[1] Catalysis Science and Technology, 2017, vol. 7, # 10, p. 1981 - 1985
[2] Catalysis Science and Technology, 2018, vol. 8, # 10, p. 2648 - 2653
[3] Patent: CN105524053, 2016, A. Location in patent: Paragraph 0534; 0535; 0536
[4] ACS Catalysis, 2018, vol. 8, # 5, p. 4545 - 4557
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 12, p. 3216 - 3220 |
|
|