| Identification | Back Directory | [Name]
PNU-104489 | [CAS]
177577-60-5 | [Synonyms]
U104489
U-104489
U 104489
PNU-104489
Methanesulfonamide, N-[2-[[4-[[3-[(1,1-dimethylethyl)amino]-2-pyridinyl]ethylamino]-1-piperidinyl]carbonyl]-1H-indol-5-yl]- | [Molecular Formula]
C26H36N6O3S | [MDL Number]
MFCD30607739 | [MOL File]
177577-60-5.mol | [Molecular Weight]
512.67 |
| Hazard Information | Back Directory | [Uses]
U-104489 is a HIV-1 inhibitor with the Ki values of 0.13, 0.12 and ＞ 100 μM aganist HIV-1 RT p66/p51 wild type (G190), G190A and G190E, respectively[1]. | [References]
[1] Fan N, et al. A drug resistance mutation in the inhibitor binding pocket of human immunodeficiency virus type 1 reverse transcriptase impairs DNA synthesis and RNA degradation. Biochemistry. 1996;35(30):9737-9745. DOI:10.1021/bi9600308 |
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