| Identification | Back Directory | [Name]
7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE | [CAS]
17771-33-4 | [Synonyms]
2,2-Dimethyl-7-hydroxychroman-4-one
7-hydroxy-2,2-dimethyl-4-chromanone
7-HYDROXY-2,2-DIMETHYL-CHROMAN-4-ONE
7-HYDROXY-2,2-DIMETHYL-2,3-DIHYDRO-4H-CHROMEN-4-ONE
2,3-Dihydro-7-hydroxy-2,2-dimethyl-4H-1-benzopyran-4-one
7-Hydroxy-2,2-dimethyl-3,4-dihydro-2h-1-benzopyran-4-one
2,2-Dimethyl-7-hydroxy-2,3-dihydro-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2,2-dimethyl- | [Molecular Formula]
C11H12O3 | [MDL Number]
MFCD00100268 | [MOL File]
17771-33-4.mol | [Molecular Weight]
192.21 |
| Chemical Properties | Back Directory | [Melting point ]
172 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
354.3±42.0 °C(Predicted) | [density ]
1.196±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.75±0.40(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM[1]. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells[2]. | [References]
[1] Wang J, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 2009 Mar;11(3):321-7. DOI:10.1016/j.micinf.2008.12.011
[2] Aaftaab Sethi, et al. Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins. Eur J Med Chem. 2021 Oct 15:222:113561. DOI:10.1016/j.ejmech.2021.113561 |
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