| Identification | Back Directory | [Name]
CLORGYLINE | [CAS]
17780-72-2 | [Synonyms]
m&b9302
mandb9302
clorgiline
n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylamin
n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-amin
N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine
N-Methyl-N-[3-(2,4-dichlorophenoxy)propyl]-2-propyne-1-amine
3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl- | [Molecular Formula]
C13H15Cl2NO | [MDL Number]
MFCD00052012 | [MOL File]
17780-72-2.mol | [Molecular Weight]
272.17 |
| Chemical Properties | Back Directory | [Boiling point ]
361.3±37.0 °C(Predicted) | [density ]
1.196±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
6.98±0.50(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases[1]. | [Definition]
ChEBI: An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant. | [References]
[1] Knoll J. The possible mechanisms of action of (-) deprenyl in Parkinson's disease[J]. Journal of Neural Transmission, 1978, 43: 177-198. DOI:10.1007/BF01246955 |
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