| Identification | Back Directory | [Name]
NOCICEPTIN (1-13) AMIDE | [CAS]
178064-02-3 | [Synonyms]
NOCICEPTIN (1-13)NH2
NOCICEPTIN (1-13) AMIDE
ORPHANIN FQ (1-13) AMIDE
Nociceptin (1-13)-NH2/ Orphanin FQ
(Phe1-()-Gly2)-Nociceptin (1-13) aMide
(Phe1-()-Gly2)-Orphanin FQ (1-13) aMide
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-NH2
Nociceptin (1-13) aMide
Orphanin FQ (1-13) aMide
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2
H-PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2 | [Molecular Formula]
C61H100N22O15 | [MDL Number]
MFCD01318816 | [MOL File]
178064-02-3.mol | [Molecular Weight]
1381.59 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
Soluble to 0.67 mg/ml in 20% acetonitrile | [form ]
Powder | [pka]
12.91±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
Nociceptin (1-13)，amide is a potent ORL1 receptor (opioid receptor-like 1 receptor，OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2]. | [IC 50]
NOP Receptor/ORL1 | [References]
[1] Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90. DOI:10.1038/sj.bjp.0702226
[2] Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83. DOI:10.1038/sj.bjp.0703219 |
|
|