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178249-42-8

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178249-42-8 Structure

178249-42-8 Structure
IdentificationBack Directory
[Name]

NOCICEPTIN (1-7)
[CAS]

178249-42-8
[Synonyms]

NOCICEPTIN (1-7)
Nociceptin Fragment 1-7
Orphanin FQ Fragment 1-7
[Molecular Formula]

C31H41N7O9
[MDL Number]

MFCD02684529
[MOL File]

178249-42-8.mol
[Molecular Weight]

655.7
Chemical PropertiesBack Directory
[Boiling point ]

1193.6±65.0 °C(Predicted)
[density ]

1.319±0.06 g/cm3(Predicted)
[storage temp. ]

−20°C
[form ]

Powder
[pka]

3.42±0.10(Predicted)
[Water Solubility ]

Soluble to 2 mg/ml in water
[Sequence]

Phe-Gly-Gly-Phe-Thr-Gly-Ala
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Nociceptin (1-7), also known as orphanin FQ, is identified as naturally occurring agonist of orphan opioid receptor-like ORL1 receptor.
[in vivo]

Nociceptin (1-7) (intrathecal injection; 150–1200? nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0?fmol), nociceptin-induced hyperalgesia is significantly reduced[1].

Animal Model:Mice[1]
Dosage:150–1200? nmol
Administration:Intrathecal injection; single dose
Result:Co-treatment with nociceptin could reduce hyperalgesia.
[IC 50]

NOP Receptor/ORL1
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