| Identification | Back Directory | [Name]
2-Pyrimidinamine, N-cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-, hydrochloride (1:2) | [CAS]
1782532-29-9 | [Synonyms]
2-Pyrimidinamine, N-cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-, hydrochloride (1:2) | [Molecular Formula]
C21H23ClFN5S | [MOL File]
1782532-29-9.mol | [Molecular Weight]
431.96 |
| Hazard Information | Back Directory | [Uses]
DBM 1285 dihydrochloride is an orally active TNF-α production inhibitor with anti-inflammatory effects. DBM 1285 dihydrochloride inhibits Lipopolysaccharide (LPS)-induced TNF-α secretion in various cells of macrophage/monocyte lineage[1]. | [Biological Activity]
DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active. | [storage]
Store at -20°C | [References]
[1] Jong Soon Kang, et al. DBM1285 suppresses tumor necrosis factor alpha production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J Pharmacol Exp Ther. 2010 Aug;334(2):657-64. DOI:10.1124/jpet.109.161687 |
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