| Identification | Back Directory | [Name]
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- | [CAS]
178306-52-0 | [Synonyms]
ALST-3
S-2-Hydroxy-3-methoxy-3
3-diphenylpropanoic acid
AMbrisentan InterMediate
Ambrisentan Hydroxy Impurity
Ambrisentan Related compound A
Ambrisentan Hydroxy Acid Impurity
Ambrisentan Hydroxy Acid Impurity (S-Isomer)
(S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid
(2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
(S)-2-Hydroxyl -3-Methoxy-3,3-diphenylpropanoic acid
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, (αS)-
Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, (αS)-
"(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid"Q: What is
"(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What is the CAS Number of
"(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What is the storage condition of
"(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What are the applications of
"(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C16H16O4 | [MDL Number]
MFCD11113284 | [MOL File]
178306-52-0.mol | [Molecular Weight]
272.298 |
| Chemical Properties | Back Directory | [Melting point ]
121 °C | [Boiling point ]
430.3±45.0 °C(Predicted) | [density ]
1.248 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly) | [form ]
Solid | [pka]
3.24±0.28(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)/t14-/s3 | [InChIKey]
RQJWOLFMWKZKCJ-WDHUHKLTNA-N | [SMILES]
C(OC)(C1=CC=CC=C1)(C1C=CC=CC=1)[C@H](O)C(=O)O |&1:15,r| |
| Questions And Answer | Back Directory | [Uses]
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity. |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
The general procedure for the synthesis of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid from 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was as follows: 500 mg (1.84 mmol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was dissolved in 8 mL of 2-propanol, followed by addition of 135 mg (0.92 mmol) of (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine. The reaction mixture was stirred under heated reflux conditions for 1 hour, then cooled to room temperature and continued stirring for 2 hours. The precipitated crystals were collected by filtration, washed with 2-propanol and finally dried under reduced pressure. The same operations as in Example 1 were performed according to the solvents listed in Table 1. | [References]
[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0041; 0042; 0045; 0046
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11-12
[3] Patent: CN104098462, 2017, B. Location in patent: Paragraph 0009; 0028; 0029; 0031
[4] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0071; 0072
[5] Patent: WO2013/57468, 2013, A1. Location in patent: Page/Page column 23-24 |
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