| Identification | Back Directory | [Name]
N-[3-(benzimidazol-1-yl)-1,4-dioxonaphthalen-2-yl]-4-nitrobenzenesulfonamide | [CAS]
1783800-77-0 | [Synonyms]
N-[3-(benzimidazol-1-yl)-1,4-dioxonaphthalen-2-yl]-4-nitrobenzenesulfonamide
Benzenesulfonamide, N-[3-(1H-benzimidazol-1-yl)-1,4-dihydro-1,4-dioxo-2-naphthalenyl]-4-nitro- | [Molecular Formula]
C23H14N4O6S | [MOL File]
1783800-77-0.mol | [Molecular Weight]
474.45 |
| Hazard Information | Back Directory | [Uses]
AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease[1]. | [in vivo]
AUTEN-67 enhances autophagy in zebrafish (10, 50 μM)and mice (e 50 μmol/g body weight, i.p.)[1].
AUTEN-67 (19 mg/kg, p.o., 3 times a week, for 3 month) restores nesting behavior and decreases APP level in the Alzheimer disease mice model[1].
| Animal Model: | Alzheimer disease model (Mice expressing the human APP)[1] | | Dosage: | 19 mg/kg, 3 times a week for 3 month | | Administration: | Oral administration | | Result: | Restored nesting behavior by around 30%.
Decreased Amyloid β levels in the hemibrain of mice.
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| [References]
[1] Papp D, et al. AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy. 2016;12(2):273-86. DOI:10.1080/15548627.2015.1082023 |
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