ChemicalBook--->CAS DataBase List--->1783816-74-9

1783816-74-9

Request For Quotation
1783816-74-9 Structure

1783816-74-9 Structure
IdentificationBack Directory
[Name]

NVS-PAK1-1
[CAS]

1783816-74-9
[Synonyms]

NVS-PAK1-1
NVS-PAK1-1 >=98% (HPLC)
NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1
(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
[Molecular Formula]

C23H25ClF3N5O
[MDL Number]

MFCD30723183
[MOL File]

1783816-74-9.mol
[Molecular Weight]

479.93
Chemical PropertiesBack Directory
[Boiling point ]

697.8±55.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
[form ]

powder
[pka]

14.02±0.40(Predicted)
[color ]

white to beige
[InChIKey]

OINGHOPGNMYCAB-INIZCTEOSA-N
[SMILES]

N1(C(NC(C)C)=O)CC[C@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C3=CC=C(Cl)C=C32)C1
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313
Hazard InformationBack Directory
[Uses]

NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.
[Biochem/physiol Actions]

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
[in vivo]

NVS-PAK1-1 shows a relatively poor stability in rat liver microsomes (RLM) and this would limit its application for in vivo studies (t1/2 in RLM 3.5 min)[1].

[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

NVS-PAK1-1(1783816-74-9)1HNMR
1783816-74-9 suppliers list
Company Name: Chengdu Celes Technology Co., Ltd  Gold
Telephone: 19982073091
Website:
Company Name: Deyang Sino Biotech. Co., LTD  Gold
Telephone: +86-19182167371
Website: http://www.synlord.com
Company Name: Lexeon Biotech (Chengdu) Co., Ltd.  Gold
Telephone: 19982073091
Website:
Company Name: Sigma-Aldrich  
Telephone: 021-61415566 800-8193336
Website: https://www.sigmaaldrich.cn
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Telephone: 021-52996696，15000506266 15000506266
Website: http://www.bioll.com
Company Name: Shanghaizehan biopharma technology co., Ltd.  
Telephone: 021-61350663 13052117465
Website: http://www.zehanbiopharma.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 15026964105
Website: www.shyuanye.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Telephone: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Telephone: QQ：65489617 13301690235
Website: www.atkchemical.com/
Company Name: Chuzhou KeMail Chemical Technology Co., Ltd  
Telephone: 0550-5196001 15000891977
Website: https://www.chemicalbook.com/ShowSupplierProductsList19947/0_EN.htm
Company Name: Shanghai Biopharmaleader Co., Ltd.  
Telephone: +86 18721201413
Website: www.biopharmaleader.com
Company Name: Chengdu Henghui Pharmaceutical Co., Ltd.  
Telephone: 86-028-89481236 13540674322 15828370308
Website: www.chemicalbook.com/ShowSupplierProductsList30420/0_EN.htm
Company Name: Twochem Co.Ltd.  
Telephone: 021-58111628 15800915896
Website: cn.twochem.com
Company Name: Taizhou Crene Biotechnology Co. Ltd.  
Telephone: +86-0576-88813233 +86-13396860566
Website: http://www.pharm-intermediates.com
Company Name: Tianjin Kaifu Pharmaceutical Technology Co., Ltd.  
Telephone: 18081075745
Website: www.chemicalbook.com/ShowSupplierProductsList31177/0_EN.htm
Company Name: Henan Weituxi Chemical Technology Co., Ltd.  
Telephone: 0371-63284658 18135795563
Website: https://www.chemicalbook.com/supplier/15004346/
Company Name: Changzhou Chenhong Biotechnology Co., Ltd.  
Telephone: +86-0519-85788828 +86-13775037613
Website: http://www.chemrenblock.com/
Company Name: Shanghai Zeye Biotechnology Co., Ltd.  
Telephone: 021-57896695 13122526631
Website: www.chemicalbook.com/showsupplierproductslist729391/0_en.htm
Tags:1783816-74-9 Related Product Information
872511-34-7 1562338-42-4 300842-64-2 1092499-93-8 1310746-10-1 1874276-76-2 1313363-54-0