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1786411-17-3

1786411-17-3 Structure

1786411-17-3 Structure
IdentificationBack Directory
[Name]

Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 2',4',5',7'-tetrafluoro-3-oxo-3',6'-bis[[(trifluoromethyl)sulfonyl]oxy]-
[CAS]

1786411-17-3
[Synonyms]

HKSOX-1
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 2',4',5',7'-tetrafluoro-3-oxo-3',6'-bis[[(trifluoromethyl)sulfonyl]oxy]-
[Molecular Formula]

C23H6F10O11S2
[MOL File]

1786411-17-3.mol
[Molecular Weight]

712.4
Chemical PropertiesBack Directory
[Boiling point ]

710.8±60.0 °C(Predicted)
[density ]

2.02±0.1 g/cm3(Predicted)
[pka]

3.55±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2??) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2??-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2?? roles in inflammation, mitochondrial stress, and other physiological processes[1].
[References]

[1] Fluorescent Probe HKSOX?1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo
1786411-17-3 suppliers list
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 15801484223;
Website: http://www.jm-bio.com/
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Website: www.ruidiresearch.com
Company Name: MedChemExpress  
Tel: 021-58955995
Website: www.medchemexpress.com
Tags:1786411-17-3 Related Product Information

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