ChemicalBook--->CAS DataBase List--->1786438-30-9

1786438-30-9

Request For Quotation
1786438-30-9 Structure

1786438-30-9 Structure
IdentificationBack Directory
[Name]

(R)-CR8 (trihydrochloride)
[CAS]

1786438-30-9
[Synonyms]

(R)?-?CR8 (trihydrochloride)
CR8, (R)-Isomer trihydrochloride
[Molecular Formula]

C24H30ClN7O
[MDL Number]

MFCD18086880
[MOL File]

1786438-30-9.mol
[Molecular Weight]

468
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 62.5 mg/mL (115.54 mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].
[in vivo]

(R)-CR8 trihydrochloride (5?mg/Kg; i.p.) results in a significant reduction in lesion size at 28 days in histological assessment[2].

Animal Model:Adult (10 to 12 weeks old) male Sprague-Dawley rats (310 to 330?g)[2]
Dosage:5?mg/Kg
Administration:i.p.
Result:Resulted in a significant reduction in lesion size.
[IC 50]

CDK1/cyclinB1: 0.09 μM (IC50); cdk2/cyclin A: 0.072 μM (IC50); CDK2/cyclinE: 0.041 μM (IC50); Cdk5/p25: 0.11 μM (IC50); CDK7/cyclin H: 1.1 μM (IC50); CDK9/Cyclin T: 0.18 μM (IC50); CK1δ/ε: 0.4 μM (IC50)
[storage]

Store at +4°C
[References]

[1] Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. DOI:10.1038/onc.2008.191
[2] Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. DOI:10.1038/jcbfm.2013.228
[3] S?abicki M, et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K [published online ahead of print, 2020 Jun 3]. Nature. 2020;10.1038/s41586-020-2374-x. DOI:10.1038/s41586-020-2374-x
Spectrum DetailBack Directory
[Spectrum Detail]

(R)-CR8 (trihydrochloride)(1786438-30-9)1HNMR
1786438-30-9 suppliers list
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 15026964105
Website: www.shyuanye.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Telephone: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Telephone: QQ：65489617 13301690235
Website: www.atkchemical.com/
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Telephone: 13504435624
Website: https://www.wodapro.com
Company Name: Shanghai Dongyang Biotechnology Co., Ltd.  
Telephone: 0512-13601744364 13601744364
Website: www.chemicalbook.com/showsupplierproductslist1201937/0_en.htm
Company Name: Shanghai hongqu biomedical technology co. LTD  
Telephone: 88888888888
Website: www.chemicalbook.com/ShowSupplierProductsList873228/0_EN.htm
Company Name: Suzhou Chenrui Biotechnology Co. LTD  
Telephone: 17625585511
Website: www.chemicalbook.com/ShowSupplierProductsList660257/0_EN.htm
Company Name: cjbscvictory  
Telephone: 13348960310 13348960310
Website: www.weikeqi-biotech.com/
Company Name: Nantong Hi-Future Biotechnology Co., Ltd  
Telephone: +86-0513; 18051384581
Website: https://www.chemhifuture.com/
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Telephone: 010-60605840
Website: http://www.jm-bio.com/
Company Name: InvivoChem  
Telephone: 13549236410
Website: https://www.invivochem.cn/
Company Name: Shanghai Zhongzechuan Pharmaceutical Technology Co., LTD  
Telephone: 25888888 15021253307
Website: www.wesyntech.com/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Aikon International Limited  
Telephone: 17714375163
Website: www.aikonchem.com
Company Name: Xuchang Fengfei New Materials Technology Co., Ltd  
Telephone: 19713077352; 19713077352
Website: http://fengfeinew.webh.testwebsite.cn/
Company Name: Suzhou Haiben Pharmaceutical Co., Ltd  
Telephone: 19353112242
Website:
Company Name: https://hanhongsci.com/  
Telephone: 021-54306202 18917919676
Website: https://www.hanhongsci.com/
Company Name: Shanghai Aladdin Biochemical Technology Co.,Ltd.  
Telephone: 6206333 13167063860
Website: www.aladdin-e.com/
Tags:1786438-30-9 Related Product Information
154-17-6 4474-91-3 555-60-2