| Identification | Back Directory | [Synonyms]
CAS
XPO2
CSE1
Exportin-2
CALCISEPTINE
CSE1 chromosome segregation 1-like
chromosome segregation 1-like protein
CALCISEPTINE, DENDROASPIS POLYLEPIS POLYLEPIS
Anti-CSE1L, N-Terminal antibody produced in rabbit
Calciseptine from Dendroaspis polylepis polylepis (black mamba)
ANTI-CELLULAR APOPTOSIS SUSCEPTIBILITY(C-TERMINAL) antibody produced in rabbit
ARG-ILE-CYS-TYR-ILE-HIS-LYS-ALA-SER-LEU-PRO-ARG-ALA-THR-LYS-THR-CYS-VAL-GLU -ASN-THR-CYS-TYR-LYS-MET-PHE-ILE-ARG-THR-GLN-ARG-GLU-TYR-ILE-SER-GLU-ARG-GLY-CYS-GLY-CYS-PRO-THR-ALA-MET-TRP-PRO-TYR-GLN-THR-GLU-CYS-CYS-LYS-GLY-ASP-CYS -ASN-LYS |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [Sequence]
Arg-Ile-Cys-Tyr-Ile-His-Lys-Ala-Ser-Leu-Pro-Arg-Ala-Thr-Lys-Thr-Cys-Val-Glu-Asn-Thr-Cys-Tyr-Lys-Met-Phe-Ile-Arg-Thr-Gln-Arg-Glu-Tyr-Ile-Ser-Glu-Arg-Gly-Cys-Gly-Cys-Pro-Thr-Ala-Met-Trp-Pro-Tyr-Gln-Thr-Glu-Cys-Cys-Lys-Gly-Asp-Arg-Cys-Asn-Lys (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52; Cys53-Cys58) |
| Hazard Information | Back Directory | [Uses]
Calciseptine, a natural?neurotoxin?isolated from the black mamba Dendroaspis p. polylepis venom. Calciseptine consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type?calcium channel[1]. | [IC 50]
L-type calcium channel: 15 nM (IC50) | [References]
[1] H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3): 878–882. DOI:10.1073/pnas.91.3.878 |
|
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Alomone Labs
|
| Tel: |
4008-168-068 13121892008 |
| Website: |
www.alomone.com |
|