Identification | Back Directory | [Name]
AQ 148 | [CAS]
178820-70-7 | [Synonyms]
AQ 148 (2S)-1-[(S)-benzamido-benzyl-methylazaniumyl]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-phenylbutan-2-olate | [Molecular Formula]
C30H37N3O4 | [MOL File]
178820-70-7.mol | [Molecular Weight]
503.639 |
Hazard Information | Back Directory | [Description]
AQ 148 is a potent competitive inhibitor of HIV-1 PR. | [Uses]
AQ148 is a HIV-1 protease inhibitor (Ki=137 nM). The IC50 values ??of AQ148 for the inhibition of HIV-1, HIV-2 and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively[1]. | [References]
[1] Rutenber, et al. "A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere." Bioorganic & medicinal chemistry 4.9 (1996): 1545-1558. DOI:10.1016/0968-0896(96)00147-2 |
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