| Identification | Back Directory | [Name]
H-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-PRO-OH | [CAS]
178823-45-5 | [Synonyms]
MBP (83-99) (bovine)
MYELIN BASIC PROTEIN (83-99) (BOVINE)
8:PN:US20130183327 SEQID:9 claimed sequence
Myelin Basic Protein (83-99) (bovine)
MBP (83-99) (bovine)
H-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-PRO-OH | [Molecular Formula]
C93H143N25O24 | [MDL Number]
MFCD02261957 | [MOL File]
178823-45-5.mol | [Molecular Weight]
1995.28 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C
| [pka]
3.39±0.20(Predicted) | [Sequence]
H-Glu-Asn-Pro-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-OH |
| Hazard Information | Back Directory | [Uses]
MBP (83-99) is a MBP-specific T cell lines recognizing the immunodominant epitope. MBP (83-99) induces proliferation and IFN-γ secreting of T cells[1][2]. | [in vivo]
MBP(83-99) (50 μg; subcutaneous injection; once) generates weak IFN-γ secreting T cells in immunize SJL/J mice[2]. | [References]
[1] Hemmer B, et al. Human T-cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function, and phenotype. Neurology. DOI:10.1212/wnl.49.4.1116
[2] Katsara M, et al. A double mutation of MBP(83-99) peptide induces IL-4 responses and antagonizes IFN-gamma responses. J Neuroimmunol. 2008 Aug 30;200(1-2):77-89. DOI:10.1016/j.jneuroim.2008.06.013 |
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