| Identification | Back Directory | [Name]
RZCPXIZGLPAGEV-SUHLLOIRSA-N | [CAS]
179094-11-2 | [Synonyms]
(±)5-iPF2α-VI
RZCPXIZGLPAGEV-SUHLLOIRSA-N
Prosta-6,14-dien-1-oic acid, 5,9,11-trihydroxy-, (6E,8β,9α,11α,14Z)- | [Molecular Formula]
C20H34O5 | [MOL File]
179094-11-2.mol | [Molecular Weight]
354.49 |
| Chemical Properties | Back Directory | [Boiling point ]
525.4±50.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .5 mg/ml | [pka]
4.68±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III). However, 8-isoprostane is a minor isoprostane constituent when compared to some of the other isomers which form in natural conditions of oxidative stress. (±)5-iPF2α-VI is an isoprostane from the unique Type VI class of isoprostanes. This class has been shown to be one of the major isoprostane products, in contrast to 8-isoprostane. In addition to being produced in greater abundance than 8-isoprostane, Type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples. | [Uses]
(±)5-iPF2α-VI (5-iso Prostaglandin F2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress[1]. | [storage]
Store at -20°C | [References]
[1] Morita Y, et al. Simultaneous analyses of urinary eicosanoids and related mediators identified tetranor-prostaglandin E metabolite as a novel biomarker of diabetic nephropathy. J Lipid Res. 2021;62:100120. DOI:10.1016/j.jlr.2021.100120 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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