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179246-08-3

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179246-08-3 Structure

179246-08-3 Structure
IdentificationBack Directory
[Name]

GW 284543 hydrochloride - UNC 10225170 hydrochloride
[CAS]

179246-08-3
[Synonyms]

GW 284543 hydrochloride
GW 284543 hydrochloride - UNC 10225170 hydrochloride
[Molecular Formula]

C23H21ClN2O3
[MDL Number]

MFCD32644597
[MOL File]

179246-08-3.mol
[Molecular Weight]

408.88
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,Room Temperature
Safety DataBack Directory
[Symbol(GHS) ]

GHS hazard pictograms
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
[IC 50]

MEK5
[References]

[1] Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. DOI:10.1016/j.ccell.2018.10.001
Spectrum DetailBack Directory
[Spectrum Detail]

GW 284543 hydrochloride - UNC 10225170 hydrochloride(179246-08-3)1HNMR
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