179246-08-3

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179246-08-3 Structure

Identification	Back Directory
[Name] GW 284543 hydrochloride - UNC 10225170 hydrochloride
[CAS] 179246-08-3
[Synonyms] GW 284543 hydrochloride GW 284543 hydrochloride - UNC 10225170 hydrochloride
[Molecular Formula] C23H21ClN2O3
[MDL Number] MFCD32644597
[MOL File] 179246-08-3.mol
[Molecular Weight] 408.88

Chemical Properties	Back Directory
[storage temp. ] Sealed in dry,Room Temperature

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Information	Back Directory
[Uses] GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
[IC 50] MEK5
[References] [1] Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. DOI:10.1016/j.ccell.2018.10.001

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