ChemicalBook--->CAS DataBase List--->1793063-59-8

1793063-59-8

1793063-59-8 Structure

1793063-59-8 Structure
IdentificationBack Directory
[Name]

HEC 72702)
[CAS]

1793063-59-8
[Synonyms]

HEC 72702)
HEC72702 (HEC-72702
2-Morpholinepropanoic acid, 4-[[(6R)-6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-3,6-dihydro-2-(2-thiazolyl)-4-pyrimidinyl]methyl]-, (2R)-
[Molecular Formula]

C24H26BrFN4O5S
[MDL Number]

MFCD32868931
[MOL File]

1793063-59-8.mol
[Molecular Weight]

581.45
Chemical PropertiesBack Directory
[Boiling point ]

669.0±65.0 °C(Predicted)
[density ]

1.60±0.1 g/cm3(Predicted)
[pka]

4.50±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 μM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers[1].
[in vivo]

HEC72702 (50, 100 mg/kg; p.o.; daily for 7 days) dose-dependently reduces HBV DNA in both the plasma and livers copies[1].
Pharmacokinetic Parameters of HEC72702 in Male Sprague-Dawley rats[1].

dose (mg/kg)iv (2)po (5)
AUC(0-24 h) (h*ng/mL)41104900
CL (mL/min/kg)8.11
VSS (L/kg)0.41
F %47.7
Male Sprague-Dawley rats, 2 mg/kg iv; 5 mg/kg po[1].
Animal Model:6-7 weeks, 16-18 g, Female BALB/c mice(HDI mouse model)[1]
Dosage:50, 100 mg/kg
Administration:P.o.; daily for 7 days
Result:Demonstrated a dose-dependent reduction of HBV DNA in the plasma of infected mice.
[References]

[1] Ren Q, et al. 3-((R)-4-(((R)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4. J Med Chem. 2018 Feb 8;61(3):1355-1374. DOI:10.1021/acs.jmedchem.7b01914
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