| Identification | Back Directory | [Name]
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate | [CAS]
179386-44-8 | [Synonyms]
CS-414
U95666E
PNU 95666
PNU 95666E
Sumanirole maleate
PNU-95,666 maleate
PubChem ID: 9818478
CID 9818479 maleate
U 95666E(Sumanirole maleate)
Sumanirole maleate >=98% (HPLC)
U95666E;PNU 95666;PNU 95666E;SUMANIROLE
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1) | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C11H13N3O.C4H4O4 | [MDL Number]
MFCD09832637 | [MOL File]
179386-44-8.mol | [Molecular Weight]
319.313 |
| Chemical Properties | Back Directory | [Melting point ]
200-208°C (dec.) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble10mg/mL, clear | [form ]
powder | [color ]
white to beige | [Optical Rotation]
[α]/D -22 to -32°, c = 1 in H2O | [Water Solubility ]
H2O: 10mg/mL, clear | [InChI]
1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1 | [InChIKey]
VOJRMYBBPKNLLI-ORHWHDKWSA-N | [SMILES]
O=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O |
| Hazard Information | Back Directory | [Uses]
Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000). | [Biochem/physiol Actions]
Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease. | [IC 50]
D2 Receptor | [storage]
Store at -20°C |
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