| Identification | Back Directory | [Name]
AH 11110 HYDROCHLORIDE | [CAS]
179388-65-9 | [Synonyms]
AH 11110
AH11110HCl
AH 11110 HYDROCHLORIDE
AH 11110 >98% (HPLC), solid
4-IMINO-1-(2-PHENYLPHENOXY)-4-PIPERIDINEBUTAN-2-OL HYDROCHLORIDE
1-[BIPHENYL-2-YLOXY]-4-IMINO-4-PIPERIDIN-1-YL-BUTAN-2-OL HYDROCHLORIDE | [Molecular Formula]
C21H27ClN2O2 | [MDL Number]
MFCD03093187 | [MOL File]
179388-65-9.mol | [Molecular Weight]
374.91 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
H2O: ~2.5 mg/mL, soluble | [form ]
solid | [color ]
slightly yellow | [Water Solubility ]
Soluble to 25 mM in water |
| Hazard Information | Back Directory | [Uses]
AH 11110 Hydrochloride is an α1B-adrenoceptor selective drug. AH 11110 Hydrochloride has been shown to interact with α1-adrenoceptors as well as α2-adrenoceptors. | [Biological Activity]
A subtype-selective ligand for the α 1B -adrenoceptor. The pK i values for binding to rat fibroblast cell membranes expressing α 1B (hamster), α 1A (bovine) and α 1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α 1 subtypes and α 2 receptors in smooth muscle preparations. | [IC 50]
α1B-adrenergic receptor | [storage]
Store at RT | [References]
[1]. erami c, zhang h, ho jg, et al. alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. am j physiol heart circ physiol, 2002, 283(4): h1577-1587.
[2]. eltze m, k?nig h, ullrich b, et al. failure of ah11110a to functionally discriminate between alpha(1)-adrenoceptor subtypes a, b and d or between alpha(1)- and alpha(2)-adrenoceptors. eur j pharmacol, 2001, 415(2-3): 265-276. |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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