| Identification | Back Directory | [Name]
4-Quinazolinamine, N-(1-ethyl-3-piperidinyl)-6-iodo-2-(trifluoromethyl)- | [CAS]
179598-53-9 | [Synonyms]
PD159790
PD-159790
PD 159790
4-Quinazolinamine, N-(1-ethyl-3-piperidinyl)-6-iodo-2-(trifluoromethyl)- | [Molecular Formula]
C16H18F3IN4 | [MOL File]
179598-53-9.mol | [Molecular Weight]
450.24 |
| Hazard Information | Back Directory | [Uses]
PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM[1][2][3]. | [References]
[1] Janet Maguire, et al. Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels. J Cardiovasc Pharmacol. 2004 Nov:44 Suppl 1:S27-9. DOI:10.1097/01.fjc.0000166219.65593.af
[2] F D Russell, et al. Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells. Circ Res. 1999 Apr 30;84(8):891-6. DOI:10.1161/01.res.84.8.891
[3] K Ahn, et al. Novel selective quinazoline inhibitors of endothelin converting enzyme-1. Biochem Biophys Res Commun. 1998 Feb 4;243(1):184-90. DOI:10.1006/bbrc.1998.8081 |
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