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DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes[1][2]. | [in vivo]
DiaPep277 (50 μg; i.p.; single dosage) causes strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses[2]. | Animal Model: | Female NOD mice (diabetes model)[2] | | Dosage: | 50 μg | | Administration: | i.p.; single dosage | | Result: | Caused strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses. |
| [References]
[1] Eldor R, et al. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev. 2009 May;25(4):316-20. DOI:10.1002/dmrr.942
[2] Elias D, et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3088-91. DOI:10.1073/pnas.88.8.3088 |
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