| Identification | Back Directory | [Name]
4(1H)-Quinolinone, 5-fluoro-3-methyl-2-[4-[[4-[(trifluoromethyl)thio]phenyl]methyl]phenyl]- | [CAS]
1801444-69-8 | [Synonyms]
RYL-552S
4(1H)-Quinolinone, 5-fluoro-3-methyl-2-[4-[[4-[(trifluoromethyl)thio]phenyl]methyl]phenyl]- | [Molecular Formula]
C24H17F4NOS | [MOL File]
1801444-69-8.mol | [Molecular Weight]
443.46 |
| Chemical Properties | Back Directory | [Boiling point ]
490.3±45.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.76±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RYL-552S kills drug-resistant strains of Plasmodium falciparum. RYL-552S can efficiently kill asexual blood-stage parasites in vitro[1]. | [IC 50]
Plasmodium | [References]
[1] Yiqing Yang, et al. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria. J Med Chem. 2017 Mar 9;60(5):1994-2005. DOI:10.1021/acs.jmedchem.6b01733 |
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