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18016-80-3

18016-80-3 Structure

18016-80-3 Structure
IdentificationBack Directory
[Name]

S-(-)-LISURIDE
[CAS]

18016-80-3
[Synonyms]

Lisurid
LISURIDE
Lysuride
CABERQOLINE
Mesorgydine
Prestwick_525
S-(-)-LISURIDE
Lisuride (S)(-)
(+)-(5R,8S)-Lisuride
Methylergol carbamide
Lisuride DISCONTINUED PLEASE SEE L469078
1,1-Diethyl-3-(D-6-Methylisoergolen-8-yl)urea
N-(D-6-Methyl-8-isoergolenyl)-N',N'-diethylurea
3-(9,10-Didehydro-6-Methylergolin-8α-yl)-1,1-diethylurea
3-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-1,1-diethylurea
N'-[(8α)-9,10-Didehydro-6-Methylergolin-8-yl]-N,N-diethylurea
N'-[(5β)-9,10-Didehydro-6-methylergoline-8α-yl]-N,N-diethylurea
Urea, N'-[(8α)-9,10-didehydro-6-methylergolin-8-yl]-N,N-diethyl-
9-(3,3-Diethylureido)-4,6,6a,7,8,9-hexahydro-7-Methylindolo[4,3-fg]quinoline
1,1-Diethyl-3-((6aR,9S)-7-Methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)urea
[EINECS(EC#)]

241-925-1
[Molecular Formula]

C20H26N4O
[MDL Number]

MFCD00274053
[MOL File]

18016-80-3.mol
[Molecular Weight]

338.45
Chemical PropertiesBack Directory
[Melting point ]

186°
[alpha ]

D20 +313° (c = 0.60 in pyridine)
[Boiling point ]

603.4±55.0 °C(Predicted)
[density ]

1.23±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

13.06±0.20(Predicted)
[color ]

Off-white to light yellow
[CAS DataBase Reference]

18016-80-3
Safety DataBack Directory
[Symbol(GHS) ]


GHS06
[Signal word ]

Danger
[Hazard statements ]

H300-H330-H310
[Precautionary statements ]

P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501
Hazard InformationBack Directory
[Uses]

A dopamine and serotonin receptor partial agonist with high affinity for the dopamine D2, D3 and D4 receptors, as well as serotonin 5-HT1A and 5-HT2A/C receptors. An anti-parkinson agent.
[Definition]

ChEBI:Lisuride is a monocarboxylic acid amide. It has a role as an antiparkinson drug, a serotonergic agonist, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an ergoline.
[in vivo]

lisuride (30~100 μg/kg) decreases the rate of dopa formation[2].

[IC 50]

D2 Receptor
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