| Identification | Back Directory | [Name]
ITH 12575 | [CAS]
1802013-08-6 | [Synonyms]
ITH 12575
ITH12575 >=98% (HPLC)
7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one | [Molecular Formula]
C18H18ClNOS | [MDL Number]
MFCD30720887 | [MOL File]
1802013-08-6.mol | [Molecular Weight]
331.86 |
| Chemical Properties | Back Directory | [Boiling point ]
484.5±45.0 °C(Predicted) | [density ]
1.219±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.34±0.40(Predicted) | [color ]
White to off-white | [InChI]
1S/C18H18ClNOS/c1-11(2)13-5-3-4-6-14(13)18-15-9-12(19)7-8-16(15)20-17(21)10-22-18/h3-9,11,18H,10H2,1-2H3,(H,20,21) | [InChIKey]
RDMUJSJZBYAAEF-UHFFFAOYSA-N | [SMILES]
CC(C)C1=C(C2C(C=C(Cl)C=C3)=C3NC(CS2)=O)C=CC=C1 |
| Hazard Information | Back Directory | [Uses]
7-?Chloro-?1,?5-?dihydro-?5-?[2-?(1-?methylethyl)?phenyl]?-4,?1-benzothiazepin-?2(3H)?-?one can be used to study the physiological roles of the mitochondrial sodium /calcium exchanger related to neurodegeneration. | [Biological Activity]
ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. at higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1a Ca2+ channel th at plays a key role in the neuronal electrical activity. | [storage]
Store at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|