| Identification | Back Directory | [Name]
Methyltetrazine-PEG4-Amine | [CAS]
1802908-05-9 | [Synonyms]
Methyltetrazine-PEG4-Amine
Methyltetrazine-PEG4-amine HCl salt
2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethanamine
Ethanamine, 2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C17H25N5O4 | [MDL Number]
MFCD28334553 | [MOL File]
1802908-05-9.mol | [Molecular Weight]
363.41 |
| Chemical Properties | Back Directory | [Boiling point ]
558.7±60.0 °C(Predicted) | [density ]
1.186±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [pka]
8.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-PEG4-amine is an aqueous soluble PEGylation reagent containing a free amine and a methyltetrazine group. Methyl group improves the stability and hydrophilic PEG spacer increases water-solubility. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene). | [Uses]
Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Henan Alfachem Co.,Ltd.
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0371-55051623 18137891487 |
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www.chemicalbook.com/supplier/14555231/ |
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