| Identification | Back Directory | [Name]
1H-Indole-2-carboxylic acid, 5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, (2E)-2-(1H-indol-3-ylmethylene)hydrazide | [CAS]
1804127-83-0 | [Synonyms]
CDK9-IN-18
1H-Indole-2-carboxylic acid, 5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, (2E)-2-(1H-indol-3-ylmethylene)hydrazide | [Molecular Formula]
C27H20N8O | [MOL File]
1804127-83-0.mol | [Molecular Weight]
472.5 |
| Hazard Information | Back Directory | [Uses]
CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis. | [References]
[1] Hu H, et al. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors. Bioorg Chem. 2020 Sep;102:104064. DOI:10.1016/j.bioorg.2020.104064 |
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