| Identification | Back Directory | [Name]
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- | [CAS]
1805789-54-1 | [Synonyms]
1), (3R,4R)-
PPDA-001 HCL SALT
ICEC0942 (CT7001)
CT7001 hydrochloride
ICEC 0942 hydrochloride
Samuraciclib hydrochloride
ICEC0942;ICE C0942;ICE-C0942;CT7001;CT-7001;CT 7001
(3R,4R)-4-(((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-olhydrochloride
3-Piperidinol, 4-3-(1-methylethyl)-7-(phenylmethyl)aminopyrazolo1,5-apyrimidin-5-ylaminomethyl-, hydrochloride (1
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)- | [Molecular Formula]
C22H31ClN6O | [MDL Number]
MFCD31657343 | [MOL File]
1805789-54-1.mol | [Molecular Weight]
430.98 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Soluble | [form ]
A solid | [color ]
White to light yellow | [InChIKey]
YMNPLAHCOLEZJE-ALSDZXMDNA-N | [SMILES]
N(C1=CC(NC[C@H]2CCNC[C@@H]2O)=NC2=C(C(C)C)C=NN12)CC1C=CC=CC=1.Cl |&1:6,11,r| |
| Hazard Information | Back Directory | [Uses]
CT7001 Hydrochloride, is a selective CDK7 inhibitor. | [in vivo]
Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors[1].
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The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts[1]. | Animal Model: | Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells[1] | | Dosage: | 100 mg/kg | | Administration: | Oral gavage; daily; for 14 days | | Result: | At day 14, tumor growth was inhibited by 60%.
|
| [IC 50]
CDK7: 41 nM (IC50); CDK2: 578 nM (IC50); CDK1: 1.8 μM (IC50); CDK4: 49 μM (IC50); CDK5: 9.4 μM (IC50); CDK6: 34 μM (IC50); CDK9: 1.2 μM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
TaiChem Taizhou Limited
|
| Tel: |
052386810091 |
| Website: |
https://www.chemicalbook.com/supplier/11410902/1.htm |
|