180608-78-0

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180608-78-0 Structure

Identification	Back Directory
[Name] 1H-Pyrrole-2,5-dione, 1-(5-hydroxypentyl)
[CAS] 180608-78-0
[Synonyms] N-(5-Hydroxypentyl)maleimide 1H-Pyrrole-2,5-dione, 1-(5-hydroxypentyl)
[Molecular Formula] C9H13NO3
[MDL Number] MFCD28397100
[MOL File] 180608-78-0.mol
[Molecular Weight] 183.2

Chemical Properties	Back Directory
[Boiling point ] 336.2±25.0 °C(Predicted)
[density ] 1?+-.0.06 g/cm3(Predicted)
[form ] Oil
[pka] 15.14±0.10(Predicted)
[color ] Colorless to light yellow

Hazard Information	Back Directory
[Uses] N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].
[IC 50] Non-cleavable Linker
[References] [1] Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.

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