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180637-89-2

180637-89-2 Structure

180637-89-2 Structure
IdentificationBack Directory
[Name]

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE
[CAS]

180637-89-2
[Synonyms]

Eletriptan Impurity 23
(R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole
(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole
3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE
(R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole
3-[[(2R)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole
1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethenyl]-
[Molecular Formula]

C22H24N2O2S
[MDL Number]

MFCD09751002
[MOL File]

180637-89-2.mol
[Molecular Weight]

380.5
Chemical PropertiesBack Directory
[Boiling point ]

617.7±55.0 °C(Predicted)
[density ]

1.263
[solubility ]

soluble in Dichloromethane, Dimethylformamide, Methanol
[pka]

16.92±0.30(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS05,GHS08,GHS07
[Signal word ]

Danger
[Hazard statements ]

H302-H317-H318-H373
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P305+P351+P338-P310-P260-P314-P501
Hazard InformationBack Directory
[Chemical Properties]

Red Solid
[Uses]

(R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole is the free base of (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole Hydrobromide (B120725), which is an impurity of Eletriptan (E505000). Eletriptan is a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines (1,2,3). (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole is also an intermediate in the synthesis of 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-1-[1-[3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indol-5-yl]-2-(phenylsulfonyl)ethyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole (M320195).
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