| Identification | Back Directory | [Name]
4-Methoxycyclohexanol | [CAS]
18068-06-9 | [Synonyms]
4-Metho×ycyclohe×anol
4-methoxycyclohexan-1-ol
Cyclohexanol, 4-methoxy- | [Molecular Formula]
C7H14O2 | [MDL Number]
MFCD00019333 | [MOL File]
18068-06-9.mol | [Molecular Weight]
130.18 |
| Chemical Properties | Back Directory | [Boiling point ]
204-205 °C(Press: 731 Torr) | [density ]
0.99±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
liquid | [pka]
14.98±0.40(Predicted) | [color ]
Colourless to light yellow | [InChI]
InChI=1S/C7H14O2/c1-9-7-4-2-6(8)3-5-7/h6-8H,2-5H2,1H3 | [InChIKey]
PFTGXSGDFZZZFY-UHFFFAOYSA-N | [SMILES]
C1(O)CCC(OC)CC1 |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of p-methoxycyclohexanol from p-hydroxyanisole was as follows: 400 g of 4-methoxyphenol was dissolved in 450 mL of methanol and 40 g of 5 wt% palladium-carbon catalyst was added. The reaction system was pressurized to 7 MPa under hydrogen atmosphere and stirred at 140 °C for 5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was subjected to distillation under reduced pressure to recover the solvent. The final p-methoxycyclohexanol was obtained with a purity of about 97% and a yield of 98.5%. | [References]
[1] Tetrahedron Letters, 1994, vol. 35, # 39, p. 7151 - 7154
[2] New Journal of Chemistry, 2006, vol. 30, # 3, p. 447 - 457
[3] RSC Advances, 2014, vol. 4, # 6, p. 2729 - 2732
[4] Patent: CN108409547, 2018, A. Location in patent: Paragraph 0022; 0024; 0025; 0028; 0031; 0034
[5] Patent: WO2011/104338, 2011, A1. Location in patent: Page/Page column 49-50 |
|
|