| Identification | Back Directory | [Name]
1-Phenyl-1H-imidazole-4-carboxylic acid | [CAS]
18075-64-4 | [Synonyms]
1-Phenyl-1H-imidazole-4-carboxylic acid
1H-Imidazole-4-carboxylic acid, 1-phenyl-
1-Phenyl-1H-imidazole-4-carboxylic acid 97% | [Molecular Formula]
C10H8N2O2 | [MDL Number]
MFCD13193504 | [MOL File]
18075-64-4.mol | [Molecular Weight]
188.18 |
| Chemical Properties | Back Directory | [Boiling point ]
424.5±18.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
1.48±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1-phenyl-1H-imidazole-4-carboxylic acid from methyl 1-phenyl-1H-imidazole-4-carboxylate: LiOH-H2O (143 mg, 3.4 mmol) was added to a stirred methyl 1-phenyl-1H-imidazole-4-carboxylic acid (231 mg, 1.1 mmol) solution in a mixture of THF (3 mL), MeOH (1 mL), and H2O ( 1 mL) in mixed solvents and continued stirring for 3 hours at room temperature. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. Subsequently, cold water was added and acidified with 10% aqueous HCl and the precipitated solid was collected to give 180 mg (83.7% yield) of 1-phenyl-1H-imidazole-4-carboxylic acid. | [References]
[1] Patent: US2009/239810, 2009, A1. Location in patent: Page/Page column 81
[2] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 24
[3] Patent: WO2017/103614, 2017, A1. Location in patent: Page/Page column 67 |
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