| Identification | Back Directory | [Name]
Propargyl-PEG2-t-butyl ester | [CAS]
1807503-80-5 | [Synonyms]
Propargyl-PEG2-Boc
Propargyl-PEG2-COOtBu
Alkyne-PEG2-CH2CH2COOtBu
Propargyl-PEG2-t-Bu Ester
PROPARGYL-PEG2-CH2CH2COOTBU
Propargyl-PEG2-t-butyl ester
tert-butyl 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoate
Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C12H20O4 | [MDL Number]
MFCD28505565 | [MOL File]
1807503-80-5.mol | [Molecular Weight]
228.28 |
| Chemical Properties | Back Directory | [Boiling point ]
290.5±20.0 °C(Predicted) | [density ]
1.007±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG2-t-butyl ester is a PEG linker that enables Click Chemistry reactions with azide-bearing compounds or biomolecules; copper will be required for catalyzation. Under acidic conditions, the t-butyl group can be removed. | [Uses]
Propargyl-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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