| Identification | Back Directory | [Name]
Sulfamic acid, 4-[[[4-[4-(4-bromophenyl)-2-pyrimidinyl]-1-piperazinyl]carbonyl]amino]phenyl ester | [CAS]
1807520-24-6 | [Synonyms]
hCAII-IN-1
Sulfamic acid, 4-[[[4-[4-(4-bromophenyl)-2-pyrimidinyl]-1-piperazinyl]carbonyl]amino]phenyl ester | [Molecular Formula]
C21H21BrN6O4S | [MOL File]
1807520-24-6.mol | [Molecular Weight]
533.4 |
| Hazard Information | Back Directory | [Uses]
hCAII-IN-1 (compound 7f) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with Kis of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has the potential for the research of cancer diseases[1]. | [References]
[1] Nocentini A, et al. Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors. Eur J Med Chem. 2020;186:111896. DOI:10.1016/j.ejmech.2019.111896 |
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