| Identification | Back Directory | [Name]
Methylamino-PEG1-t-butyl ester | [CAS]
1807521-03-4 | [Synonyms]
MeNH-PEG1-COOtBu Methylamino-PEG1-Boc Methylamino-PEG1-t-butyl ester tert-Butyl 3-[2-(methylamino)ethoxy]propanoate Propanoic acid, 3-[2-(methylamino)ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C10H21NO3 | [MDL Number]
MFCD28155197 | [MOL File]
1807521-03-4.mol | [Molecular Weight]
203.28 |
| Chemical Properties | Back Directory | [Boiling point ]
266.7±15.0 °C(Predicted) | [density ]
0.957±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DCM | [form ]
Liquid | [pka]
9.51±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Methylamino-PEG1-t-butyl ester is a PEG linker containing a methylamine group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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