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1807521-03-4

1807521-03-4 Structure

1807521-03-4 Structure
IdentificationBack Directory
[Name]

Methylamino-PEG1-t-butyl ester
[CAS]

1807521-03-4
[Synonyms]

MeNH-PEG1-COOtBu
Methylamino-PEG1-Boc
Methylamino-PEG1-t-butyl ester
tert-Butyl 3-[2-(methylamino)ethoxy]propanoate
Propanoic acid, 3-[2-(methylamino)ethoxy]-, 1,1-dimethylethyl ester
[Molecular Formula]

C10H21NO3
[MDL Number]

MFCD28155197
[MOL File]

1807521-03-4.mol
[Molecular Weight]

203.28
Chemical PropertiesBack Directory
[Boiling point ]

266.7±15.0 °C(Predicted)
[density ]

0.957±0.06 g/cm3(Predicted)
[solubility ]

Soluble in Water, DCM
[form ]

Liquid
[pka]

9.51±0.10(Predicted)
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

Methylamino-PEG1-t-butyl ester is a PEG linker containing a methylamine group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
[Uses]

Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs; Alkyl/ether
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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