| Identification | Back Directory | [Name]
Acetamide, 2-amino-N-[5-[6-chloro-5-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-3-pyridinyl]-4-methyl-2-thiazolyl]- | [CAS]
1807551-44-5 | [Synonyms]
PI3KD/VIN01
PI3KD/V-IN-01
PI3KD/V IN 01
Acetamide, 2-amino-N-[5-[6-chloro-5-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-3-pyridinyl]-4-methyl-2-thiazolyl]- | [Molecular Formula]
C21H24ClN5O3S2 | [MOL File]
1807551-44-5.mol | [Molecular Weight]
494.03 |
| Hazard Information | Back Directory | [Description]
PI3KD/V-IN-01 is a highly potent ATP-competitive PI3Kδ/Vps34 dual inhibitor. In cells, PI3KD/V-IN-01 showed 30-300 fold selectivity between PI3Kδ and other class I PI3K isoforms. PI3KD/V-IN-01 exhibited better anti-proliferative activity against AML, CLL and Burkitt lymphoma cell lines than known selective PI3Kδ and Vps34 inhibitors. | [Uses]
PI3K-IN-12 (comp 76) is a PI3K inhibitor[1]. | [References]
[1] NEW PI3K KINASE INHBITORS. Patent. WO2016101553A1. |
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