| Identification | Back Directory | [Name]
1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- | [CAS]
1807758-81-1 | [Synonyms]
SIRT7 inhibitor 97491
N1-(5-(4-Chlorophenyl)oxazol-2-yl)benzene-1,3-diamine
1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
SIRT7,inhibit,SIRT7 inhibitor 97491,p53 K373/382,Sirtuin,tumor,SIRT-7 inhibitor 97491,deacetylase,Apoptosis,Inhibitor | [Molecular Formula]
C15H12ClN3O | [MDL Number]
MFCD32708524 | [MOL File]
1807758-81-1.mol | [Molecular Weight]
285.73 |
| Chemical Properties | Back Directory | [Boiling point ]
489.9±55.0 °C(Predicted) | [density ]
1.354±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.30±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1]. | [in vivo]
SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1]. | Animal Model: | Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1] | | Dosage: | 2 mg/kg | | Administration: | Intraperitoneally injected; for 3 weeks, except on weekends. | | Result: | Inhibited cancer growth in vivo. |
| [IC 50]
SIRT7: 325 nM (IC50) | [References]
[1] Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457. DOI:10.1016/j.bbrc.2018.11.120 |
|
| Company Name: |
Cochemical Ltd.
|
| Tel: |
029-86115547 17791676824 |
| Website: |
http://www.cochemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|