| Identification | Back Directory | [Name]
1H-Purine-2,6-dione, 3-[3-(dimethylamino)propyl]-3,7-dihydro-1-hydroxy-7-(2-phenylethyl)- | [CAS]
1807775-88-7 | [Synonyms]
3-[3-(dimethylamino)propyl]-1-hydroxy-7-(2-phenylethyl)purine-2,6-dione 1H-Purine-2,6-dione, 3-[3-(dimethylamino)propyl]-3,7-dihydro-1-hydroxy-7-(2-phenylethyl)- | [Molecular Formula]
C18H23N5O3 | [MOL File]
1807775-88-7.mol | [Molecular Weight]
357.41 |
| Chemical Properties | Back Directory | [Boiling point ]
604.6±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.51±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 μM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 μM[1]. | [References]
[1] Jadhav GP, et al., Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4219-24. DOI:10.1016/j.bmcl.2015.07.095 |
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