| Identification | Back Directory | [Name]
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE | [CAS]
18080-67-6 | [Synonyms]
Conoidin A
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
Quinoxaline, 2,3-bis(bromomethyl)-, 1,4-dioxide
2,3-bis(broMoMethyl)-1-oxoquinoxalin-1-iuM-4(1H)-olate | [Molecular Formula]
C10H8Br2N2O2 | [MDL Number]
MFCD00186742 | [MOL File]
18080-67-6.mol | [Molecular Weight]
347.99 |
| Chemical Properties | Back Directory | [Melting point ]
180-190 °C (decomp) | [Boiling point ]
512.3±60.0 °C(Predicted) | [density ]
1.95±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml | [form ]
A crystalline solid | [pka]
1.91±0.30(Predicted) | [color ]
White to yellow | [InChI]
1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2 | [InChIKey]
DQKNFTLRMZOAMG-UHFFFAOYSA-N | [SMILES]
BrCC1=C(N(c2c(cccc2)[N+]1=O)[O-])CBr |
| Hazard Information | Back Directory | [Uses]
Conoidin A is a peroxiredoxin inhibitor. | [Biological Activity]
Cell permeable: yes''Primary Target
Peroxiredoxin''Reversible: no''Target IC50: 23 μM for blocking TgPrxII hyperperoxidation activity | [in vivo]
Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST-segment elevation. Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre-treatment with conoidin A abolishs the effect of Luteolin. Pre-treatment with conoidin A also prevents Luteolin-reduced activities of CK-MB, AST and LDH in vivo[3]. | Animal Model: | Rat myocardial I/R model[3] | | Dosage: | 5?mg/kg | | Administration: | Intraperitoneal injection; 5?mg/kg; for three successive days before MI/R injury | | Result: | Significantly reversed the antioxidative effect of Luteolin.
Impaired the protective effects of luteolin. |
| [IC 50]
Toxoplasma |
|
| Company Name: |
Candia Thamtech Company Limited
|
| Tel: |
0371-86615086 18203638366 0371-86159066 13526786601 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15771/0_EN.htm |
|