| Identification | Back Directory | [Name]
(1-(3-Iodophenyl)-4-(3-Nitrophenyl)-1,2,3-Triazole) | [CAS]
1809031-84-2 | [Synonyms]
PMI >=98% (HPLC)
(1-(3-Iodophenyl)-4-(3-Nitrophenyl)-1,2,3-Triazole)
1H-1,2,3-Triazole, 1-(3-iodophenyl)-4-(3-nitrophenyl)- | [Molecular Formula]
C14H9IN4O2 | [MOL File]
1809031-84-2.mol | [Molecular Weight]
392.15 |
| Chemical Properties | Back Directory | [Boiling point ]
553.3±60.0 °C(Predicted) | [density ]
1.81±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 1 mg/mL (2.55 mM; ultrasonic and adjust pH to 3 with 0.1 M HCL) | [form ]
Solid | [pka]
-1.89±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1]. | [storage]
Store at -20°C | [References]
[1] East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96. DOI:10.1016/j.chembiol.2014.09.019 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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