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1809249-37-3

1809249-37-3 Structure

1809249-37-3 Structure
IdentificationBack Directory
[Name]

GS5734
[CAS]

1809249-37-3
[Synonyms]

GS5734
Ragoli
Remdesivir
Remdesivir API
Redecivir (API)
GS5734Remdesivir
Remdesivir Powder
Remdesivir liquid
Remdesivir (GS-5734)
remdesivir producing
Remdesivir EP/USP/BP
high purity Remdesivir
Remdesivir lypholized powder
remdesivir producing The finished product
Remdesivir*(Available for selected markets)
L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
2-ethylbutyl ((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-6-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-{4-aminopyrrolo[2,1- f][1,2,4]triazin-7-yl}-5-cyano-3,4-dihydroxyoxolan- 2-yl]methoxy}(phenoxy)phosphoryl]amino}propan oate
(S)-2-ethylbutyl2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
[EINECS(EC#)]

210-629-4
[Molecular Formula]

C27H35N6O8P
[MOL File]

1809249-37-3.mol
[Molecular Weight]

602.576
Chemical PropertiesBack Directory
[density ]

1.47±0.1 g/cm3(Predicted)
[pka]

12.00±0.70(Predicted)
Questions And AnswerBack Directory
[Mechanism of action]

As an adenosine nucleoside triphosphate analog (GS-443902),the active metabolite of remdesivir interferes with the action of viral RNA-dependent RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production.In some viruses, such as the respiratory syncytial virus, it causes the RNA-dependent RNA polymerases to pause, but its predominant effect (as in Ebola) is to induce an irreversible chain termination. Unlike with many other chain terminators, this is not mediated by preventing addition of the immediately subsequent nucleotide, but is instead delayed, occurring after five additional bases have been added to the growing RNA chain.For the RNA-Dependent RNA Polymerase of MERS-CoV, SARS-CoV-1, and SARS-CoV-2, arrest of RNA synthesis occurs after incorporation of three additional nucleotides.Hence, remdesivir is classified as a direct-acting antiviral agent that works as a delayed chain terminator.
[side effect]

The most common adverse effects in people treated with remdesivir were respiratory failure and blood biomarkers of organ impairment, including low albumin, low potassium, low count of red blood cells, low count of thrombocytes, and elevated bilirubin (jaundice).Other reported adverse effects include gastrointestinal distress, elevated transaminase levels in the blood (liver enzymes), infusion site reactions, and electrocardiogram abnormalities. Remdesivir may cause infusion‐related reactions, including low blood pressure, nausea, vomiting, sweating or shivering.
Hazard InformationBack Directory
[Description]

Remdesivir, sold under the brand name Veklury,is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences.It is administered via injection into a vein.During the COVID-19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID-19 in around 50 countries.Updated guidelines from the World Health Organization in November 2020 include a conditional recommendation against the use of remdesivir for the treatment of COVID-19.
[Uses]

Remdesivir was originally developed to treat hepatitis C,and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID-19.
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