| Identification | Back Directory | [Name]
Acutumidine | [CAS]
18145-26-1 | [Synonyms]
Acutumidine
(1R,3'aS,5S,7'aS,9'S)-9'-Chloro-2',3'-dihydro-5-hydroxy-4,6',7'-trimethoxyspiro[3-cyclopentene-1,10'-[3a,7a]propano[1H]indole]-2,5'(4'H)-dione | [Molecular Formula]
C18H22ClNO6 | [MOL File]
18145-26-1.mol | [Molecular Weight]
383.823 |
| Chemical Properties | Back Directory | [Melting point ]
239-241 °C (decomp) | [Boiling point ]
693.1±55.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [pka]
11.06±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Acutumidine (compound 4) is an alkaloid with anti-HBV activity that can be isolated from Hypserpa nitida Miers. Acutumidine inhibits the production of HBsAg in Hep G2.2.15 cells stably transfected with HBV genome with an IC50 value of 2.023 mM[1]. | [Definition]
ChEBI: Acutumidine is an alkaloid. | [References]
[1] Pi Cheng, et al. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorganic & medicinal chemistry letters 17.19 (2007): 5316-5320. DOI:10.1016/j.bmcl.2007.08.027 |
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