| Identification | Back Directory | [Name]
6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE | [CAS]
181468-88-2 | [Synonyms]
PD 160170
6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE | [Molecular Formula]
C18H17N3O4S | [MDL Number]
MFCD00945695 | [MOL File]
181468-88-2.mol | [Molecular Weight]
371.41 |
| Chemical Properties | Back Directory | [Boiling point ]
646.6±55.0 °C(Predicted) | [density ]
1.379±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Powder | [pka]
-1.16±0.12(Predicted) |
| Hazard Information | Back Directory | [Uses]
PD 160170 is a compound developed to inhibit low-risk myelodysplastic syndrome-associated anemia with activities that promote red blood cell transfusion independence and increase hemoglobin. | [Definition]
ChEBI: 5-nitro-6-(2-propan-2-ylphenyl)sulfonyl-8-quinolinamine is a nitro compound and a member of quinolines. | [Biological Activity]
Potent, selective non-peptidic neuropeptide Y 1 receptor antagonist (K i = 48 nM); selective over Y 2 and Y 5 receptors (K i > 10 μ M). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC 50 = 8.2 nM). | [References]
[1] 8-Amino-5-nitro-6-phenoxyquinolines: potential non-peptidic neuropeptide Y receptor ligands |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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