| Identification | Back Directory | [Name]
HUMAN EOTAXIN | [CAS]
NoCAS | [Synonyms]
EOT
CCL11
EOTAXIN
MGC22554
HUMAN CCL11
CCL11, HUMAN
HUMAN EOTAXIN
EOTAXIN, HUMAN
EOTAXIN-1, HUMAN
Eotaxin from mouse
RECOMBINANT HUMAN EOTAXIN
Rabbit Anti-CCL11 antibody
Small inducible cytokine A11
EOTAXIN, HUMAN, RECOMBINANT, E COLI
Recombinant Human CCL11 Protein, No Tag
HUMAN EOTAXIN CHEMICALLY SYNTHESIZED CHEMOKINE
Eosinophil chemotactic protein chemokine (C-C motif) ligand 11
H-Gly-Pro-Ala-Ser-Val-Pro-Thr-Thr-Cys-Cys-Phe-Asn-Leu-Ala-Asn-Arg-Lys-Ile-Pro-Leu-Gln-Arg-Leu-Glu-Ser-Tyr-Arg-Arg-Ile-Thr-Ser-Gly-Lys-Cys-Pro-Gln-Lys-Ala-Val-Ile-Phe-Lys-Thr-Lys-Leu-Ala-Lys-Asp-Ile-Cys-Ala-Asp-Pro-Lys-Lys-Lys-Trp-Val-Gln-Asp-Ser-Met-Lys-Tyr-Leu-Asp-Gln-Lys-Ser-Pro-Thr-Pro-Lys-Pro-OH | [MDL Number]
MFCD01093487 |
| Hazard Information | Back Directory | [Biological Activity]
Eotaxin is a chemoattractant for eosinophilsand is involved inflammatory diseasessuch as asthma. It is induced by glucocorticoids and cytokines. Along with interleukin-5 (IL-5) it results in airway hyperresponsiveness (AHR)and hencelung inflammatory disorders. In humansit leads to respiratory syncytial virus (RSV) vaccine-enhanced diseaseand the eosinophils are also responsible for the elimination of virus. It might also be involved in the pathophysiology of inflammatory bowel diseases which involve eosinophils. It can lead to the production of reactive oxygen speciesthusresulting in damaged tissue. It is overexpressed in multiple diseases such as allergic rhinitisnasal polyposisendometriosis and Hodgkin′s disease. |
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